Does Felodipine Interact with Phenytoin?
CDI records a major classification for Felodipine and Phenytoin. The stored summary is: Anticonvulsant that considerably reduces felodipine plasma concentrations to approximately 6% of levels in healthy volunteers; alternative antihypertensive therapy should be considered. The mechanism involves induction of felodipine metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Felodipine Class
- Dihydropyridine Calcium Channel Blocker
- Phenytoin Class
- Anti-epileptic Agent
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Induction of felodipine metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Felodipine and your doctor is considering prescribing Phenytoin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider