Does Fenofibrate Interact with Rosuvastatin?
Fenofibrate and Rosuvastatin have a moderate drug interaction according to U.S. FDA drug labeling data. No clinically significant increase in AUC observed, but risk of myopathy is increased with concomitant use of fenofibrates. Caution should be used. The mechanism involves increased myopathy risk despite minimal pharmacokinetic interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Fenofibrate Class
- Peroxisome Proliferator Receptor alpha Agonist
- Rosuvastatin Class
- HMG-CoA Reductase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Fenofibrate and Rosuvastatin occurs because increased myopathy risk despite minimal pharmacokinetic interaction. Clinically, this means no clinically significant increase in auc observed, but risk of myopathy is increased with concomitant use of fenofibrates. caution should be used. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Fenofibrate and your doctor is considering prescribing Rosuvastatin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider