Home›Fluoxetine Hydrochloride›Fluoxetine Hydrochloride + Midazolam

Does Fluoxetine Hydrochloride Interact with Midazolam?

Fluoxetine Hydrochloride and Midazolam have a unknown drug interaction according to U.S. FDA drug labeling data. Additionally, in vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least 100 times more potent than fluoxetine or norfluoxetine as an inhibitor of the metabolism of several substrates for this enzyme, including astemizole, cisapride, and midazolam. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Fluoxetine Hydrochloride Class
Serotonin Reuptake Inhibitor
Midazolam Class
Benzodiazepine
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Fluoxetine Hydrochloride and your doctor is considering prescribing Midazolam (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Fluoxetine Hydrochloride(Fluoxetine)+💊 Midazolam(Nayzilam)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Serotonin Reuptake Inhibitor
Drug B class
Benzodiazepine
Source
FDA drug label - fluoxetine hydrochloride

What this means in plain English

Additionally, in vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least 100 times more potent than fluoxetine or norfluoxetine as an inhibitor of the metabolism of several substrates for this enzyme, including astemizole, cisapride, and midazolam.

About Fluoxetine Hydrochloride and Midazolam

Fluoxetine Hydrochloride is a Serotonin Reuptake Inhibitor, while Midazolam is a Benzodiazepine. Midazolam is also sold under the brand name Nayzilam. Fluoxetine Hydrochloride is taken by mouth, whereas Midazolam is given by intravenous (IV) infusion. Both Fluoxetine Hydrochloride and Midazolam carry an FDA boxed warning — the agency's most serious safety designation.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Fluoxetine Hydrochloride and Midazolam against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.