Does Fluticasone Propionate And Salmeterol Interact with Ritonavir?
CDI records a contraindicated classification for Fluticasone Propionate And Salmeterol and Ritonavir. The stored summary is: Strong CYP3A4 inhibitor significantly increases fluticasone propionate exposure and reduces serum cortisol. Postmarketing reports of systemic corticosteroid effects including Cushing's syndrome and adrenal suppression. The mechanism involves cyp3a4 inhibition increases systemic corticosteroid and cardiovascular adverse effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Ritonavir Class
- Cytochrome P450 3A Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A4 inhibition increases systemic corticosteroid and cardiovascular adverse effects
What To Tell Your Doctor or Pharmacist
If you are taking Fluticasone Propionate And Salmeterol and your doctor is considering prescribing Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider