Does Furosemide Interact with Epoprostenol?
Furosemide and Epoprostenol have a minor drug interaction according to U.S. FDA drug labeling data. Epoprostenol decreases furosemide clearance by 13%, but this change is not likely to be clinically significant. The mechanism involves decreased oral clearance of furosemide. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Furosemide Class
- Loop Diuretic
- Epoprostenol Class
- Prostacycline Vasodilator
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Furosemide and Epoprostenol occurs because decreased oral clearance of furosemide. Clinically, this means epoprostenol decreases furosemide clearance by 13%, but this change is not likely to be clinically significant. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Furosemide and your doctor is considering prescribing Epoprostenol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider