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Does Furosemide Interact with Milrinone Lactate In Dextrose?

Furosemide and Milrinone Lactate In Dextrose have a contraindicated drug interaction according to U.S. FDA drug labeling data. Immediate chemical interaction with formation of precipitate when furosemide is injected into IV line containing milrinone. Furosemide should not be administered in IV lines containing milrinone. The mechanism involves chemical incompatibility resulting in precipitate formation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Furosemide Class
Loop Diuretic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Furosemide and Milrinone Lactate In Dextrose occurs because chemical incompatibility resulting in precipitate formation. Clinically, this means immediate chemical interaction with formation of precipitate when furosemide is injected into iv line containing milrinone. furosemide should not be administered in iv lines containing milrinone. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Furosemide and your doctor is considering prescribing Milrinone Lactate In Dextrose (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Furosemide(Disal)+💊 Milrinone Lactate In Dextrose(Milrinone Lactate In Dextrose)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Loop Diuretic
Drug B class
—
Source
NLP:milrinone lactate

What this means in plain English

Immediate chemical interaction with formation of precipitate when furosemide is injected into IV line containing milrinone. Furosemide should not be administered in IV lines containing milrinone.

About Furosemide and Milrinone Lactate In Dextrose

Furosemide is a Loop Diuretic. Furosemide is also sold under the brand name Disal. Furosemide is given by intramuscular injection, whereas Milrinone Lactate In Dextrose is given by intravenous (IV) infusion. Furosemide additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Chemical incompatibility resulting in precipitate formation"

📖 Source: NLP:milrinone lactate

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.