Does Glecaprevir And Pibrentasvir Interact with Norethindrone Acetateethinyl Estradiol?
Glecaprevir And Pibrentasvir and Norethindrone Acetateethinyl Estradiol have a major drug interaction according to U.S. FDA drug labeling data. Coadministration is not recommended due to potential for ALT elevations. The mechanism involves hepatic enzyme elevation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Glecaprevir And Pibrentasvir Class
- Hepatitis C Virus NS5A Inhibitor
- Norethindrone Acetateethinyl Estradiol Class
- Estrogen
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Glecaprevir And Pibrentasvir and Norethindrone Acetateethinyl Estradiol occurs because hepatic enzyme elevation. Clinically, this means coadministration is not recommended due to potential for alt elevations. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Glecaprevir And Pibrentasvir and your doctor is considering prescribing Norethindrone Acetateethinyl Estradiol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider