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Does Glecaprevir And Pibrentasvir Interact with Phenytoin?

Glecaprevir And Pibrentasvir and Phenytoin have a major drug interaction according to U.S. FDA drug labeling data. May significantly decrease plasma concentrations of glecaprevir and pibrentasvir, leading to reduced therapeutic effect. Use is not recommended. The mechanism involves induces p-gp and cyp3a. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Glecaprevir And Pibrentasvir Class
Hepatitis C Virus NS5A Inhibitor
Phenytoin Class
Anti-epileptic Agent
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Glecaprevir And Pibrentasvir and Phenytoin occurs because induces p-gp and cyp3a. Clinically, this means may significantly decrease plasma concentrations of glecaprevir and pibrentasvir, leading to reduced therapeutic effect. use is not recommended. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Glecaprevir And Pibrentasvir and your doctor is considering prescribing Phenytoin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Glecaprevir And Pibrentasvir(Mavyret)+💊 Phenytoin(Phenytoin Infatabs)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Hepatitis C Virus NS5A Inhibitor
Drug B class
Anti-epileptic Agent
Source
NLP:glecaprevir and pibrentasvir

What this means in plain English

May significantly decrease plasma concentrations of glecaprevir and pibrentasvir, leading to reduced therapeutic effect. Use is not recommended.

What the FDA label says

"Induces P-gp and CYP3A"

📖 Source: NLP:glecaprevir and pibrentasvir

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.