Does Glecaprevir And Pibrentasvir Interact with Warfarin?
Glecaprevir And Pibrentasvir and Warfarin have a moderate drug interaction according to U.S. FDA drug labeling data. Clearance of HCV infection may alter hepatic function and impact INR. Frequent monitoring of INR and dose adjustments may be necessary. The mechanism involves changes in hepatic function after hcv clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Glecaprevir And Pibrentasvir Class
- Hepatitis C Virus NS5A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Glecaprevir And Pibrentasvir and Warfarin occurs because changes in hepatic function after hcv clearance. Clinically, this means clearance of hcv infection may alter hepatic function and impact inr. frequent monitoring of inr and dose adjustments may be necessary. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Glecaprevir And Pibrentasvir and your doctor is considering prescribing Warfarin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider