Does Glibenclamide Interact with Pretomanid?
Glibenclamide and Pretomanid have a unknown drug interaction according to U.S. FDA drug labeling data. BCRP substrate. In vitro studies suggest pretomanid may inhibit BCRP, potentially increasing glyburide exposure. Clinical impact unknown; monitor for adverse reactions. The mechanism involves potential bcrp transporter inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Glibenclamide Class
- Sulfonylurea
- Pretomanid Class
- Antimycobacterial
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Glibenclamide and Pretomanid occurs because potential bcrp transporter inhibition. Clinically, this means bcrp substrate. in vitro studies suggest pretomanid may inhibit bcrp, potentially increasing glyburide exposure. clinical impact unknown; monitor for adverse reactions.
What To Tell Your Doctor or Pharmacist
If you are taking Glibenclamide and your doctor is considering prescribing Pretomanid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider