Does Glyburide Metformin Hydrochloride Interact with Ranolazine?
CDI records a moderate classification for Glyburide Metformin Hydrochloride and Ranolazine. The stored summary is: OCT2/MATE inhibitor that reduces metformin clearance and may increase risk for lactic acidosis. The mechanism involves interferes with renal tubular transport of metformin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Glyburide Metformin Hydrochloride Class
- Sulfonylurea
- Ranolazine Class
- Anti-anginal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Interferes with renal tubular transport of metformin
What To Tell Your Doctor or Pharmacist
If you are taking Glyburide Metformin Hydrochloride and your doctor is considering prescribing Ranolazine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider