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Does Grazoprevir Interact with Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate?

Grazoprevir and Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate have a contraindicated drug interaction according to U.S. FDA drug labeling data. elbasvir/grazoprevir ↓ elbasvir ↓ grazoprevir Coadministration of efavirenz, emtricitabine and tenofovir disoproxil fumarate with elbasvir/grazoprevir is contraindicated [see Contraindications ( 4 )] because it may lead to loss of virologic response to elbasvir/grazoprevir. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate Class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Grazoprevir and your doctor is considering prescribing Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Grazoprevir(Zepatier)+💊 Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate(Atripla)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Source
FDA drug label - efavirenz, emtricitabine and tenofovir disoproxil fumarate

What this means in plain English

elbasvir/grazoprevir ↓ elbasvir ↓ grazoprevir Coadministration of efavirenz, emtricitabine and tenofovir disoproxil fumarate with elbasvir/grazoprevir is contraindicated [see Contraindications ( 4 )] because it may lead to loss of virologic response to elbasvir/grazoprevir.

About Grazoprevir and Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate

Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. You may recognize them by the brand names Zepatier and Atripla. Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate is taken by mouth. Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.