Does Hydrochlorothiazide Interact with Lisinopril And Hydrochlorothiazide Tablets?
Hydrochlorothiazide and Lisinopril And Hydrochlorothiazide Tablets have a major drug interaction according to U.S. FDA drug labeling data. In general, avoid combined use of RAS inhibitors, closely monitor blood pressure, renal function, and electrolytes in patients on Lisinopril and Hydrochlorothiazide Tablets and other agents that affect the RAS. Do not co-administer aliskiren with Lisinopril and Hydrochlorothiazide Tablets in patients with diabetes. Avoid use of aliskiren with Lisinopril and Hydrochlorothiazide Tablets in patients with renal impairment (GFR < 60 mL/min). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Hydrochlorothiazide Class
- Thiazide Diuretic
- Lisinopril And Hydrochlorothiazide Tablets Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Hydrochlorothiazide and your doctor is considering prescribing Lisinopril And Hydrochlorothiazide Tablets (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider