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Does Ibuprofen Interact with Pemetrexed Dipotassium?

Ibuprofen and Pemetrexed Dipotassium have a major drug interaction according to U.S. FDA drug labeling data. Ibuprofen increases pemetrexed AUC and toxicity risk, especially in patients with mild to moderate renal impairment (CrCl 45-79 mL/min). Avoid ibuprofen for 2 days before, day of, and 2 days after pemetrexed administration. The mechanism involves increased pemetrexed exposure (auc). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Ibuprofen Class
Nonsteroidal Anti-inflammatory Drug
Pemetrexed Dipotassium Class
Folate Analog Metabolic Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Ibuprofen and Pemetrexed Dipotassium occurs because increased pemetrexed exposure (auc). Clinically, this means ibuprofen increases pemetrexed auc and toxicity risk, especially in patients with mild to moderate renal impairment (crcl 45-79 ml/min). avoid ibuprofen for 2 days before, day of, and 2 days after pemetrexed administration. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Ibuprofen and your doctor is considering prescribing Pemetrexed Dipotassium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ibuprofen(Ibu)+💊 Pemetrexed Dipotassium(Pemetrexed Dipotassium)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug
Drug B class
Folate Analog Metabolic Inhibitor
Source
NLP:pemetrexed dipotassium

What this means in plain English

Ibuprofen increases pemetrexed AUC and toxicity risk, especially in patients with mild to moderate renal impairment (CrCl 45-79 mL/min). Avoid ibuprofen for 2 days before, day of, and 2 days after pemetrexed administration.

What the FDA label says

"Increased pemetrexed exposure (AUC)"

📖 Source: NLP:pemetrexed dipotassium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.