Does Infliximab Dyyb Interact with Cyclosporine?
Infliximab Dyyb and Cyclosporine have a moderate drug interaction according to U.S. FDA drug labeling data. TNF blocker may normalize CYP450 enzyme formation, potentially decreasing cyclosporine exposure. Monitor drug concentration and adjust dosage upon initiation or discontinuation. The mechanism involves suppression of cyp450 enzyme formation by tnfα during inflammation; tnf antagonism may reverse this effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Infliximab Dyyb Class
- Tumor Necrosis Factor Blocker
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Infliximab Dyyb and Cyclosporine occurs because suppression of cyp450 enzyme formation by tnfα during inflammation; tnf antagonism may reverse this effect. Clinically, this means tnf blocker may normalize cyp450 enzyme formation, potentially decreasing cyclosporine exposure. monitor drug concentration and adjust dosage upon initiation or discontinuation. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Infliximab Dyyb and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider