Does Ketoconazole Interact with Solifenacin Succinate?
Ketoconazole and Solifenacin Succinate have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use significantly increased solifenacin exposure. Dosage of solifenacin greater than 5 mg once daily is not recommended. The mechanism involves strong cyp3a4 inhibitor; solifenacin is a cyp3a4 substrate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Ketoconazole Class
- Azole Antifungal
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ketoconazole and Solifenacin Succinate occurs because strong cyp3a4 inhibitor; solifenacin is a cyp3a4 substrate. Clinically, this means concomitant use significantly increased solifenacin exposure. dosage of solifenacin greater than 5 mg once daily is not recommended. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Ketoconazole and your doctor is considering prescribing Solifenacin Succinate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider