Does Lamotrigine Chewable Dispersible Interact with Lopinavir?
Lamotrigine Chewable Dispersible and Lopinavir have a unknown drug interaction according to U.S. FDA drug labeling data. Lopinavir/ritonavir ↓ lamotrigine Decreased lamotrigine concentration approximately 50%. (7, 12.3) · Protease inhibitors lopinavir/ritonavir and atazanavir/lopinavir decrease lamotrigine exposure by approximately 50% and 32%, respectively. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Lamotrigine Chewable Dispersible Class
- Anti-epileptic Agent
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Lamotrigine Chewable Dispersible and your doctor is considering prescribing Lopinavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider