Does Letermovir Interact with Acyclovir?
Letermovir and Acyclovir have a unknown drug interaction according to U.S. FDA drug labeling data. 7.4 Drugs without Clinically Significant Interactions with PREVYMIS No clinically significant interactions were observed in adult clinical drug-drug interaction studies of letermovir and acyclovir, digoxin, mycophenolate mofetil, fluconazole, itraconazole, posaconazole, ethinyl estradiol, and levonorgestrel. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Letermovir Class
- Cytomegalovirus DNA Terminase Complex Inhibitor
- Acyclovir Class
- Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Letermovir and your doctor is considering prescribing Acyclovir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider