Does Letermovir Interact with Cyclosporine?
CDI records a moderate classification for Letermovir and Cyclosporine. The stored summary is: Co-administration requires dosage adjustment of letermovir to 240 mg once daily in adults and pediatric patients ≥12 years; dose adjustment may be needed in younger patients. The mechanism involves cyclosporine affects letermovir plasma concentrations and the magnitude of cyp3a and oatp1b1/3-mediated interactions. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Letermovir Class
- Cytomegalovirus DNA Terminase Complex Inhibitor
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Cyclosporine affects letermovir plasma concentrations and the magnitude of CYP3A and OATP1B1/3-mediated interactions
What To Tell Your Doctor or Pharmacist
If you are taking Letermovir and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider