Home›Levonorgestrelethinyl Estradiol And Ethinyl Estradiol›Levonorgestrelethinyl Estradiol And Ethinyl Estradiol + St Johns Wort

Does Levonorgestrelethinyl Estradiol And Ethinyl Estradiol Interact with St Johns Wort?

Levonorgestrelethinyl Estradiol And Ethinyl Estradiol and St Johns Wort have a major drug interaction according to U.S. FDA drug labeling data. Induces hepatic enzymes and p-glycoprotein transporter, reducing contraceptive effectiveness and potentially resulting in unscheduled bleeding. The mechanism involves induces cytochrome p450 and p-glycoprotein transporter. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Levonorgestrelethinyl Estradiol And Ethinyl Estradiol Class
Estrogen
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Levonorgestrelethinyl Estradiol And Ethinyl Estradiol and St Johns Wort occurs because induces cytochrome p450 and p-glycoprotein transporter. Clinically, this means induces hepatic enzymes and p-glycoprotein transporter, reducing contraceptive effectiveness and potentially resulting in unscheduled bleeding. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Levonorgestrelethinyl Estradiol And Ethinyl Estradiol and your doctor is considering prescribing St Johns Wort (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Levonorgestrelethinyl Estradiol And Ethinyl Estradiol(Rivelsa)+💊 St Johns Wort

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Estrogen
Drug B class
—
Source
NLP:levonorgestrel and ethinyl estradiol

What this means in plain English

Induces hepatic enzymes and p-glycoprotein transporter, reducing contraceptive effectiveness and potentially resulting in unscheduled bleeding.

What the FDA label says

"Induces cytochrome P450 and p-glycoprotein transporter"

📖 Source: NLP:levonorgestrel and ethinyl estradiol

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Levonorgestrelethinyl Estradiol And Ethinyl Estradiol and St Johns Wort against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.