Does Levothyroxine Sodium Interact with Niacin?
Levothyroxine Sodium and Niacin have a unknown drug interaction according to U.S. FDA drug labeling data. Slow-release formulation may decrease serum thyroxine-binding globulin concentration. The mechanism involves decreases serum thyroxine-binding globulin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Niacin Class
- Nicotinic Acid
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Levothyroxine Sodium and Niacin occurs because decreases serum thyroxine-binding globulin. Clinically, this means slow-release formulation may decrease serum thyroxine-binding globulin concentration.
What To Tell Your Doctor or Pharmacist
If you are taking Levothyroxine Sodium and your doctor is considering prescribing Niacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider