Does Lithium Interact with Dapagliflozin And Metformin Hydrochloride?
Lithium and Dapagliflozin And Metformin Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. SGLT2 inhibitor may decrease serum lithium concentrations. Monitor serum lithium concentration more frequently during initiation and dosage changes. The mechanism involves sglt2 inhibitor effect on lithium serum concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Dapagliflozin And Metformin Hydrochloride Class
- Sodium-Glucose Cotransporter 2 Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lithium and Dapagliflozin And Metformin Hydrochloride occurs because sglt2 inhibitor effect on lithium serum concentrations. Clinically, this means sglt2 inhibitor may decrease serum lithium concentrations. monitor serum lithium concentration more frequently during initiation and dosage changes. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lithium and your doctor is considering prescribing Dapagliflozin And Metformin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider