Does Lithium Interact with Empagliflozin Linagliptin Metformin Hydrochloride?
Lithium and Empagliflozin Linagliptin Metformin Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. SGLT2 inhibitor may decrease serum lithium concentrations, reducing therapeutic efficacy. The mechanism involves sglt2 inhibitor effect on lithium renal clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Empagliflozin Linagliptin Metformin Hydrochloride Class
- Dipeptidyl Peptidase 4 Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lithium and Empagliflozin Linagliptin Metformin Hydrochloride occurs because sglt2 inhibitor effect on lithium renal clearance. Clinically, this means sglt2 inhibitor may decrease serum lithium concentrations, reducing therapeutic efficacy. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lithium and your doctor is considering prescribing Empagliflozin Linagliptin Metformin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider