Does Lithium Interact with Mannitol?
CDI records a major classification for Lithium and Mannitol. The stored summary is: Concomitant use may increase risk of lithium toxicity, especially if hypovolemia or renal impairment develops; frequently monitor lithium concentrations and signs of toxicity. The mechanism involves increased lithium elimination and risk of toxicity with renal impairment. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Mannitol Class
- Osmotic Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased lithium elimination and risk of toxicity with renal impairment
What To Tell Your Doctor or Pharmacist
If you are taking Lithium and your doctor is considering prescribing Mannitol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider