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Does Lithium Interact with Metoprolol Tartrate And Hydrochlorothiazide?

Lithium and Metoprolol Tartrate And Hydrochlorothiazide have a major drug interaction according to U.S. FDA drug labeling data. Hydrochlorothiazide reduces renal clearance of lithium and increases risk of lithium toxicity. Monitor serum lithium concentrations. The mechanism involves reduced renal clearance of lithium. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Metoprolol Tartrate And Hydrochlorothiazide Class
Thiazide Diuretic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lithium and Metoprolol Tartrate And Hydrochlorothiazide occurs because reduced renal clearance of lithium. Clinically, this means hydrochlorothiazide reduces renal clearance of lithium and increases risk of lithium toxicity. monitor serum lithium concentrations. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Lithium and your doctor is considering prescribing Metoprolol Tartrate And Hydrochlorothiazide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lithium(Lithium)+💊 Metoprolol Tartrate And Hydrochlorothiazide(Metoprolol Tartrate And Hydrochlorothiazide)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Thiazide Diuretic
Source
NLP:metoprolol tartrate and hydrochlorothiazide

What this means in plain English

Hydrochlorothiazide reduces renal clearance of lithium and increases risk of lithium toxicity. Monitor serum lithium concentrations.

What the FDA label says

"Reduced renal clearance of lithium"

📖 Source: NLP:metoprolol tartrate and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.