Home›Lopinavir›Lopinavir + Norethindrone Acetateethinyl Estradiol

Does Lopinavir Interact with Norethindrone Acetateethinyl Estradiol?

Lopinavir and Norethindrone Acetateethinyl Estradiol have a major drug interaction according to U.S. FDA drug labeling data. Lopinavir/ritonavir decreases plasma concentrations of estrogen and progestin, potentially reducing contraceptive effectiveness. The mechanism involves decreased plasma concentrations of estrogen and progestin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Norethindrone Acetateethinyl Estradiol Class
Estrogen
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lopinavir and Norethindrone Acetateethinyl Estradiol occurs because decreased plasma concentrations of estrogen and progestin. Clinically, this means lopinavir/ritonavir decreases plasma concentrations of estrogen and progestin, potentially reducing contraceptive effectiveness. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Lopinavir and your doctor is considering prescribing Norethindrone Acetateethinyl Estradiol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lopinavir+💊 Norethindrone Acetateethinyl Estradiol(Femlyv)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Estrogen
Source
NLP:norethindrone acetate and ethinyl estradiol

What this means in plain English

Lopinavir/ritonavir decreases plasma concentrations of estrogen and progestin, potentially reducing contraceptive effectiveness.

What the FDA label says

"Decreased plasma concentrations of estrogen and progestin"

📖 Source: NLP:norethindrone acetate and ethinyl estradiol

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Lopinavir and Norethindrone Acetateethinyl Estradiol against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.