Lovastatin + Diltiazem Hydrochloride Interaction
Unknowninteraction on record
Description
In a ten-subject randomized, open-label, 4-way crossover study, coadministration of diltiazem (120 mg BID diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin.
Source: FDA drug label - diltiazem hydrochloride