Macrolide Antibiotics (E.G.%2C Erythromycin) + Oxycodone Hydrochloride Interaction

Moderateinteraction on record

Description

CYP3A4 inhibitors increase plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. Monitor for respiratory depression and sedation.

Mechanism

CYP3A4 inhibition

Source: NLP:oxycodone hydrochloride