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Does Medroxyprogesterone Acetate Interact with Estrogens Conjugated?

Medroxyprogesterone Acetate and Estrogens Conjugated have a minor drug interaction according to U.S. FDA drug labeling data. Pharmacokinetic disposition of both drugs is not altered when coadministered. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Estrogens Conjugated Class
Estrogen
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Medroxyprogesterone Acetate and your doctor is considering prescribing Estrogens Conjugated (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Medroxyprogesterone Acetate(Depo-Provera)+💊 Estrogens Conjugated(Premarin)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Estrogen
Source
NLP:estrogens, conjugated

What this means in plain English

Pharmacokinetic disposition of both drugs is not altered when coadministered.

About Medroxyprogesterone Acetate and Estrogens Conjugated

Estrogens Conjugated is an Estrogen. You may recognize them by the brand names Depo-Provera and Premarin. Medroxyprogesterone Acetate is given by intramuscular injection, whereas Estrogens Conjugated is taken by mouth. Both Medroxyprogesterone Acetate and Estrogens Conjugated carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.