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Does Medroxyprogesterone Acetate Interact with St Johns Wort?

Medroxyprogesterone Acetate and St Johns Wort have a major drug interaction according to U.S. FDA drug labeling data. CYP3A4 inducer may decrease medroxyprogesterone acetate concentrations and reduce contraceptive efficacy. Effect varies by preparation. Avoid concomitant use or use backup contraception. The mechanism involves cyp3a4 induction (preparation dependent). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Medroxyprogesterone Acetate and St Johns Wort occurs because cyp3a4 induction (preparation dependent). Clinically, this means cyp3a4 inducer may decrease medroxyprogesterone acetate concentrations and reduce contraceptive efficacy. effect varies by preparation. avoid concomitant use or use backup contraception. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Medroxyprogesterone Acetate and your doctor is considering prescribing St Johns Wort (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Medroxyprogesterone Acetate(Medroxyprogesterone Acetate)+💊 St Johns Wort

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:medroxyprogesterone acetate

What this means in plain English

CYP3A4 inducer may decrease medroxyprogesterone acetate concentrations and reduce contraceptive efficacy. Effect varies by preparation. Avoid concomitant use or use backup contraception.

What the FDA label says

"CYP3A4 induction (preparation dependent)"

📖 Source: NLP:medroxyprogesterone acetate

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.