Does Mefenamic Acid Interact with Methotrexate?
Mefenamic Acid and Methotrexate have a moderate drug interaction according to U.S. FDA drug labeling data. NSAIDs may competitively inhibit methotrexate accumulation and enhance methotrexate toxicity. Caution should be used with concomitant administration. The mechanism involves competitive inhibition of methotrexate accumulation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Mefenamic Acid Class
- Nonsteroidal Anti-inflammatory Drug
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Mefenamic Acid and Methotrexate occurs because competitive inhibition of methotrexate accumulation. Clinically, this means nsaids may competitively inhibit methotrexate accumulation and enhance methotrexate toxicity. caution should be used with concomitant administration. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Mefenamic Acid and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider