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Does Metformin Interact with Iohexol?

Metformin and Iohexol have a major drug interaction according to U.S. FDA drug labeling data. Iodinated contrast agents increase risk of metformin-induced lactic acidosis, possibly by worsening renal function. Stop metformin at or prior to IOHEXOL administration in patients with eGFR 30-60 mL/min/1.73m², hepatic impairment, alcoholism, heart failure, or intra-arterial contrast use. The mechanism involves worsening renal function. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Iohexol Class
Radiographic Contrast Agent
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Metformin and Iohexol occurs because worsening renal function. Clinically, this means iodinated contrast agents increase risk of metformin-induced lactic acidosis, possibly by worsening renal function. stop metformin at or prior to iohexol administration in patients with egfr 30-60 ml/min/1.73m², hepatic impairment, alcoholism, heart failure, or intra-arterial contrast use. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Metformin and your doctor is considering prescribing Iohexol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Metformin(Metformin)+💊 Iohexol(Omnipaque)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Radiographic Contrast Agent
Source
NLP:iohexol

What this means in plain English

Iodinated contrast agents increase risk of metformin-induced lactic acidosis, possibly by worsening renal function. Stop metformin at or prior to IOHEXOL administration in patients with eGFR 30-60 mL/min/1.73m², hepatic impairment, alcoholism, heart failure, or intra-arterial contrast use.

What the FDA label says

"Worsening renal function"

📖 Source: NLP:iohexol

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.