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Does Methotrexate Interact with Salicylates?

Methotrexate and Salicylates have a major drug interaction according to U.S. FDA drug labeling data. Caution should be used when salicylates are administered concomitantly with methotrexate. These drugs reduce tubular secretion of methotrexate and may displace it from serum albumin binding, enhancing toxicity. The mechanism involves reduce tubular secretion and displace methotrexate from serum albumin binding. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Methotrexate Class
Folate Analog Metabolic Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Methotrexate and Salicylates occurs because reduce tubular secretion and displace methotrexate from serum albumin binding. Clinically, this means caution should be used when salicylates are administered concomitantly with methotrexate. these drugs reduce tubular secretion of methotrexate and may displace it from serum albumin binding, enhancing toxicity. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Methotrexate and your doctor is considering prescribing Salicylates (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Methotrexate(Methotrexate)+💊 Salicylates

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Folate Analog Metabolic Inhibitor
Drug B class
—
Source
NLP:methotrexate

What this means in plain English

Caution should be used when salicylates are administered concomitantly with methotrexate. These drugs reduce tubular secretion of methotrexate and may displace it from serum albumin binding, enhancing toxicity.

What the FDA label says

"Reduce tubular secretion and displace methotrexate from serum albumin binding"

📖 Source: NLP:methotrexate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.