Does Methotrexate Sodium Interact with Pyrimethamine?
CDI records a major classification for Methotrexate Sodium and Pyrimethamine. The stored summary is: Antifolate drug that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and potentially reducing clinical effectiveness. The mechanism involves increases methotrexate exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Pyrimethamine Class
- Dihydrofolate Reductase Inhibitor Antimalarial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increases methotrexate exposure
What To Tell Your Doctor or Pharmacist
If you are taking Methotrexate Sodium and your doctor is considering prescribing Pyrimethamine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider