Does Metoclopramide Interact with Fosfomycin Tromethamine?
Metoclopramide and Fosfomycin Tromethamine have a moderate drug interaction according to U.S. FDA drug labeling data. Metoclopramide increases gastrointestinal motility and lowers serum concentration and urinary excretion of fosfomycin when co-administered. The mechanism involves increased gastrointestinal motility reduces fosfomycin absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Metoclopramide and Fosfomycin Tromethamine occurs because increased gastrointestinal motility reduces fosfomycin absorption. Clinically, this means metoclopramide increases gastrointestinal motility and lowers serum concentration and urinary excretion of fosfomycin when co-administered. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Metoclopramide and your doctor is considering prescribing Fosfomycin Tromethamine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider