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Does Metoclopramide Interact with Insulin Human?

Metoclopramide and Insulin Human have a major drug interaction according to U.S. FDA drug labeling data. Metoclopramide alters gastric emptying, which may cause insulin to act before food leaves the stomach, leading to hypoglycemia. Insulin dosage or timing may require adjustment. The mechanism involves altered drug delivery affecting timing of insulin action. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Insulin Human Class
Insulin
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Metoclopramide and Insulin Human occurs because altered drug delivery affecting timing of insulin action. Clinically, this means metoclopramide alters gastric emptying, which may cause insulin to act before food leaves the stomach, leading to hypoglycemia. insulin dosage or timing may require adjustment. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Metoclopramide and your doctor is considering prescribing Insulin Human (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Metoclopramide(Pileran)+💊 Insulin Human(Myxredlin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Insulin
Source
NLP:metoclopramide

What this means in plain English

Metoclopramide alters gastric emptying, which may cause insulin to act before food leaves the stomach, leading to hypoglycemia. Insulin dosage or timing may require adjustment.

About Metoclopramide and Insulin Human

Insulin Human is an Insulin. You may recognize them by the brand names Pileran and Myxredlin. Metoclopramide is taken by mouth, whereas Insulin Human is given by intravenous (IV) infusion. Both Metoclopramide and Insulin Human carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"Altered drug delivery affecting timing of insulin action"

📖 Source: NLP:metoclopramide

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.