Does Midazolam Hydrochloride Interact with Ranitidine?
Midazolam Hydrochloride and Ranitidine have a minor drug interaction according to U.S. FDA drug labeling data. Minimal interaction; slightly increases midazolam steady-state concentration but no clinically significant change in sedation or cognitive function observed. The mechanism involves minor effect on metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Ranitidine Class
- Histamine-2 Receptor Antagonist
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Midazolam Hydrochloride and Ranitidine occurs because minor effect on metabolism. Clinically, this means minimal interaction; slightly increases midazolam steady-state concentration but no clinically significant change in sedation or cognitive function observed. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Midazolam Hydrochloride and your doctor is considering prescribing Ranitidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider