Does Nevirapine Interact with Lopinavir And Ritonavir?
Nevirapine and Lopinavir And Ritonavir have a moderate drug interaction according to U.S. FDA drug labeling data. Dose adjustment to 500/125 mg tablets or 533/133 mg oral solution twice daily recommended due to decreased lopinavir exposure. The mechanism involves nevirapine induces metabolism of lopinavir via cyp3a and 2b6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Nevirapine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Lopinavir And Ritonavir Class
- Protease Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nevirapine and Lopinavir And Ritonavir occurs because nevirapine induces metabolism of lopinavir via cyp3a and 2b6. Clinically, this means dose adjustment to 500/125 mg tablets or 533/133 mg oral solution twice daily recommended due to decreased lopinavir exposure. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Nevirapine and your doctor is considering prescribing Lopinavir And Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider