Does Nifedipine Interact with Quinidine?
Nifedipine and Quinidine have a moderate drug interaction according to U.S. FDA drug labeling data. CYP3A substrate and inhibitor that increases nifedipine C max and AUC by 2.30 and 1.37 fold respectively, with increased heart rate up to 17.9 beats/minute. Heart rate monitoring and nifedipine dose adjustment recommended. The mechanism involves cyp3a inhibition and pharmacodynamic interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Nifedipine Class
- Dihydropyridine Calcium Channel Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nifedipine and Quinidine occurs because cyp3a inhibition and pharmacodynamic interaction. Clinically, this means cyp3a substrate and inhibitor that increases nifedipine c max and auc by 2.30 and 1.37 fold respectively, with increased heart rate up to 17.9 beats/minute. heart rate monitoring and nifedipine dose adjustment recommended. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Nifedipine and your doctor is considering prescribing Quinidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider