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Does Nitroglycerin Interact with Isradipine?

Nitroglycerin and Isradipine have a minor drug interaction according to U.S. FDA drug labeling data. Isradipine has been safely coadministered with nitroglycerin with no reported adverse effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Nitroglycerin Class
Nitrate Vasodilator
Isradipine Class
Dihydropyridine Calcium Channel Blocker
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Nitroglycerin and your doctor is considering prescribing Isradipine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Nitroglycerin(Rectiv)+💊 Isradipine

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Nitrate Vasodilator
Drug B class
Dihydropyridine Calcium Channel Blocker
Source
NLP:isradipine

What this means in plain English

Isradipine has been safely coadministered with nitroglycerin with no reported adverse effects.

About Nitroglycerin and Isradipine

Nitroglycerin is a Nitrate Vasodilator, while Isradipine is a Dihydropyridine Calcium Channel Blocker. Nitroglycerin is also sold under the brand name Rectiv. Both medications are taken by mouth. Nitroglycerin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.