Does Norethindrone Acetateethinyl Estradiol Interact with Glecaprevir And Pibrentasvir?
Norethindrone Acetateethinyl Estradiol and Glecaprevir And Pibrentasvir have a major drug interaction according to U.S. FDA drug labeling data. Coadministration is not recommended due to potential for ALT elevations. The mechanism involves hepatic enzyme elevation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Norethindrone Acetateethinyl Estradiol Class
- Estrogen
- Glecaprevir And Pibrentasvir Class
- Hepatitis C Virus NS5A Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Norethindrone Acetateethinyl Estradiol and Glecaprevir And Pibrentasvir occurs because hepatic enzyme elevation. Clinically, this means coadministration is not recommended due to potential for alt elevations. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Norethindrone Acetateethinyl Estradiol and your doctor is considering prescribing Glecaprevir And Pibrentasvir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider