Does Norethindrone Acetateethinyl Estradiol Interact with Lamotrigine?
Norethindrone Acetateethinyl Estradiol and Lamotrigine have a major drug interaction according to U.S. FDA drug labeling data. Hormonal products significantly decrease plasma concentration of lamotrigine, likely reducing seizure control; dosage adjustments of lamotrigine may be necessary. The mechanism involves induction of lamotrigine glucuronidation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Norethindrone Acetateethinyl Estradiol Class
- Estrogen
- Lamotrigine Class
- Anti-epileptic Agent
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Norethindrone Acetateethinyl Estradiol and Lamotrigine occurs because induction of lamotrigine glucuronidation. Clinically, this means hormonal products significantly decrease plasma concentration of lamotrigine, likely reducing seizure control; dosage adjustments of lamotrigine may be necessary. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Norethindrone Acetateethinyl Estradiol and your doctor is considering prescribing Lamotrigine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider