Does Ofloxacin Interact with Cimetidine?
Ofloxacin and Cimetidine have a unknown drug interaction according to U.S. FDA drug labeling data. Cimetidine has demonstrated interference with elimination of some quinolones, resulting in significant increases in half-life and AUC. Potential for interaction with ofloxacin has not been studied. The mechanism involves interference with drug elimination. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Ofloxacin Class
- Quinolone Antimicrobial
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ofloxacin and Cimetidine occurs because interference with drug elimination. Clinically, this means cimetidine has demonstrated interference with elimination of some quinolones, resulting in significant increases in half-life and auc. potential for interaction with ofloxacin has not been studied.
What To Tell Your Doctor or Pharmacist
If you are taking Ofloxacin and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider