Does Olanzapine Pamoate Interact with Fluoxetine?
Olanzapine Pamoate and Fluoxetine have a minor drug interaction according to U.S. FDA drug labeling data. Fluoxetine causes small decrease in olanzapine clearance with minimal change in steady-state concentrations; dose modification not routinely recommended. The mechanism involves cyp2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Olanzapine Pamoate and Fluoxetine occurs because cyp2d6 inhibition. Clinically, this means fluoxetine causes small decrease in olanzapine clearance with minimal change in steady-state concentrations; dose modification not routinely recommended. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Olanzapine Pamoate and your doctor is considering prescribing Fluoxetine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider