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Does Olanzapine Pamoate Interact with Warfarin?

Olanzapine Pamoate and Warfarin have a minor drug interaction according to U.S. FDA drug labeling data. Warfarin does not affect olanzapine pharmacokinetics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Minor
Management: Generally manageable
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Olanzapine Pamoate and your doctor is considering prescribing Warfarin (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Olanzapine Pamoate(Zyprexa Relprevv)+💊 Warfarin(Warfarin Sodium)

Severity & Interaction Details

✅

minor

Generally safe — minor interaction

Low clinical significance. Routine awareness is usually sufficient.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:olanzapine pamoate

What this means in plain English

Warfarin does not affect olanzapine pharmacokinetics.

About Olanzapine Pamoate and Warfarin

Olanzapine Pamoate is also sold under the brand name Zyprexa Relprevv. Olanzapine Pamoate is given by intramuscular injection, whereas Warfarin is taken by mouth. Both Olanzapine Pamoate and Warfarin carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Pin-Away PYRENTAL PAMOATE (Pyrantel base 50 mg / mL) Pinworm Treatment, 2 FL OZ (60 mL) bottle, Distabout Olanzapine Pamoate · 2023-06

FDA

FDA Safety Alert: Warfarin Sodium Tablets, USP, 5 mg, 100 Tablets per bottle, Rx Only, Manufactured for: Teva Pharmaceabout Warfarin · 2024-01

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.