Does Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide Interact with Simvastatin?
Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide and Simvastatin have a moderate drug interaction according to U.S. FDA drug labeling data. Limit simvastatin to 20 mg daily when coadministered with amlodipine. The mechanism involves amlodipine inhibits cyp3a4 metabolism of simvastatin, increasing its exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide Class
- Thiazide Diuretic
- Simvastatin Class
- HMG-CoA Reductase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide and Simvastatin occurs because amlodipine inhibits cyp3a4 metabolism of simvastatin, increasing its exposure. Clinically, this means limit simvastatin to 20 mg daily when coadministered with amlodipine. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide and your doctor is considering prescribing Simvastatin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider