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Does Olmesartan Medoxomil And Amlodipine Besylate And Hydrochloro Interact with Simvastatin?

Olmesartan Medoxomil And Amlodipine Besylate And Hydrochloro and Simvastatin have a moderate drug interaction according to U.S. FDA drug labeling data. Limit simvastatin to 20 mg daily when coadministered with amlodipine. The mechanism involves amlodipine increases simvastatin exposure via cyp3a inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Olmesartan Medoxomil And Amlodipine Besylate And Hydrochloro Class
Thiazide Diuretic
Simvastatin Class
HMG-CoA Reductase Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Olmesartan Medoxomil And Amlodipine Besylate And Hydrochloro and Simvastatin occurs because amlodipine increases simvastatin exposure via cyp3a inhibition. Clinically, this means limit simvastatin to 20 mg daily when coadministered with amlodipine. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Olmesartan Medoxomil And Amlodipine Besylate And Hydrochloro and your doctor is considering prescribing Simvastatin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Olmesartan Medoxomil And Amlodipine Besylate And Hydrochloro(Olmesartan Medoxomil And Amlodipine Besylate And Hydrochlorothiazide)+💊 Simvastatin

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
HMG-CoA Reductase Inhibitor
Source
NLP:olmesartan medoxomil and amlodipine besylate and hydrochlorothiazide

What this means in plain English

Limit simvastatin to 20 mg daily when coadministered with amlodipine.

What the FDA label says

"Amlodipine increases simvastatin exposure via CYP3A inhibition"

📖 Source: NLP:olmesartan medoxomil and amlodipine besylate and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.