Does Omeprazole Magnesium Interact with Methotrexate?
CDI records a major classification for Omeprazole Magnesium and Methotrexate. The stored summary is: Concomitant use, especially at high dose, may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to methotrexate toxicities. The mechanism involves increased serum concentrations and prolonged exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
Saved label reference on DailyMed. This identifier has not been checked here as support for the current claim.
- Stored CDI classification
- Major
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased serum concentrations and prolonged exposure
What To Tell Your Doctor or Pharmacist
If you are taking Omeprazole Magnesium and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider