Home›Oral Anticoagulants›Oral Anticoagulants + Esterified Estrogens Methyltestosterone

Does Oral Anticoagulants Interact with Esterified Estrogens Methyltestosterone?

Oral Anticoagulants and Esterified Estrogens Methyltestosterone have a major drug interaction according to U.S. FDA drug labeling data. Androgens may decrease anticoagulant requirements; patients require close monitoring, especially when androgens are started or stopped. The mechanism involves c-17 substituted derivatives of testosterone decrease anticoagulant requirements. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Major
Esterified Estrogens Methyltestosterone Class: Androgen
Management: Close medical supervision required
Data Source: U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Oral Anticoagulants and Esterified Estrogens Methyltestosterone occurs because c-17 substituted derivatives of testosterone decrease anticoagulant requirements. Clinically, this means androgens may decrease anticoagulant requirements; patients require close monitoring, especially when androgens are started or stopped. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Oral Anticoagulants and your doctor is considering prescribing Esterified Estrogens Methyltestosterone (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask how frequently you should be monitored while these are co-prescribed
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Oral Anticoagulants+💊 Esterified Estrogens Methyltestosterone(Esterified Estrogens And Methyltestosterone)

Severity & Interaction Details

⚠️

major

Use with caution — major interaction

Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

Androgen

Source

NLP:esterified estrogens and methyltestosterone

What this means in plain English

Androgens may decrease anticoagulant requirements; patients require close monitoring, especially when androgens are started or stopped.

What the FDA label says

"C-17 substituted derivatives of testosterone decrease anticoagulant requirements"

📖 Source: NLP:esterified estrogens and methyltestosterone

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Esterified Estrogens & Methyltestosterone Tablets, USP 1.25 mg/2.5 mg, 100-count bottles, Rx Only, about Esterified Estrogens Methyltestosterone · 2019-07

PubMed

Safety surveillance of esterified estrogens-methyltestosterone (Estratest and Estratest HS) replacement therapy in the United States.about Esterified Estrogens Methyltestosterone · 1997-09

Share this result:

WhatsApp Text / SMS Email

Also share on:X Facebook

Add more drugs

Check Oral Anticoagulants and Esterified Estrogens Methyltestosterone against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.