HomeOxycodoneOxycodone + Butalbital Acetaminophen Caffeine And Codeine Phosphate

Does Oxycodone Interact with Butalbital Acetaminophen Caffeine And Codeine Phosphate?

Oxycodone and Butalbital Acetaminophen Caffeine And Codeine Phosphate have a minor drug interaction according to U.S. FDA drug labeling data. If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydromorphone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Oxycodone Class
Opioid Agonist
Butalbital Acetaminophen Caffeine And Codeine Phosphate Class
Barbiturate
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Oxycodone and your doctor is considering prescribing Butalbital Acetaminophen Caffeine And Codeine Phosphate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Oxycodone(Primlev)+💊 Butalbital Acetaminophen Caffeine And Codeine Phosphate(Fioricet With Codeine)

Severity & Interaction Details

minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Opioid Agonist
Drug B class
Barbiturate
Source
FDA drug label - butalbital, acetaminophen, caffeine and codeine phosphate

What this means in plain English

If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydromorphone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.

About Oxycodone and Butalbital Acetaminophen Caffeine And Codeine Phosphate

Oxycodone is an Opioid Agonist, while Butalbital Acetaminophen Caffeine And Codeine Phosphate is a Barbiturate. Oxycodone is also sold under the brand name Primlev. Both medications are taken by mouth. Both Oxycodone and Butalbital Acetaminophen Caffeine And Codeine Phosphate carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.